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Manuel Worcel Selected Research

Hydralazine (Apresoline)

12/2014G-protein beta-3 subunit genotype predicts enhanced benefit of fixed-dose isosorbide dinitrate and hydralazine: results of A-HeFT.
8/2012Effect of fixed-dose combined isosorbide dinitrate/hydralazine in elderly patients in the African-American heart failure trial.
12/2009Relationship of quality of life scores with baseline characteristics and outcomes in the African-American heart failure trial.
11/2009Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy.
11/2008Exploring the potential synergistic action of spironolactone on nitric oxide-enhancing therapy: insights from the African-American Heart Failure Trial.
8/2007Evidence for the continued safety and tolerability of fixed-dose isosorbide dinitrate/hydralazine in patients with chronic heart failure (the extension to African-American Heart Failure Trial).
6/2007Isosorbide dinitrate and hydralazine in a fixed-dose combination produces further regression of left ventricular remodeling in a well-treated black population with heart failure: results from A-HeFT.
4/2007Early and sustained benefit on event-free survival and heart failure hospitalization from fixed-dose combination of isosorbide dinitrate/hydralazine: consistency across subgroups in the African-American Heart Failure Trial.
1/2007Influence of blood pressure on the effectiveness of a fixed-dose combination of isosorbide dinitrate and hydralazine in the African-American Heart Failure Trial.
1/2007Effects of ACE inhibitors or beta-blockers in patients treated with the fixed-dose combination of isosorbide dinitrate/hydralazine in the African-American Heart Failure Trial.
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Manuel Worcel Research Topics

Disease

17Heart Failure
12/2014 - 06/2002
2Systolic Heart Failure
11/2009 - 11/2008
1Ventricular Remodeling
06/2007
1Renal Insufficiency (Renal Failure)
12/2006
1Hypertension (High Blood Pressure)
09/2006
1Psychological Sexual Dysfunctions (Sexual Arousal Disorder)
08/2002
1Erectile Dysfunction
06/2002

Drug/Important Bio-Agent (IBA)

14Hydralazine (Apresoline)FDA LinkGeneric
12/2014 - 06/2002
14Isosorbide Dinitrate (Isordil)FDA LinkGeneric
12/2014 - 06/2002
3Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
11/2008 - 06/2002
2Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2008 - 08/2002
2Arginine (L-Arginine)FDA Link
08/2002 - 06/2002
2Glutamic Acid (Glutamate)FDA Link
08/2002 - 06/2002
2Yohimbine (Yocon)IBA
08/2002 - 06/2002
1Guanine NucleotidesIBA
12/2014
1GTP-Binding Proteins (G-Protein)IBA
12/2014
1Carrier Proteins (Binding Protein)IBA
12/2014
1Brain Natriuretic Peptide (Natrecor)FDA Link
11/2009
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
04/2009
1Angiotensin Receptor AntagonistsIBA
11/2008
1Spironolactone (Aldactone)FDA LinkGeneric
11/2008
1Mineralocorticoid Receptor AntagonistsIBA
11/2008
1AngiotensinsIBA
06/2007
1Digoxin (Digitek)FDA LinkGeneric
06/2007
1ReninIBA
06/2007
1Vasodilator Agents (Vasodilators)IBA
06/2007
1DiureticsIBA
06/2007
1CreatinineIBA
12/2006
1Hemoglobins (Hemoglobin)IBA
12/2006
1Cytochrome P-450 CYP11B2 (CYP11B2)IBA
09/2006

Therapy/Procedure

10Therapeutics
08/2012 - 06/2002
2Length of Stay
12/2014 - 12/2005